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难治性卵巢癌的新治疗策略:透明细胞癌和粘液癌
发表日期:2022-02-16

难治性卵巢癌的新治疗策略:透明细胞癌和粘液癌

Novel Therapeutic Strategies for Refractory Ovarian Cancers: Clear Cell and Mucinous Carcinomas


Ovarian clear cell and mucinous carcinomas are less sensitive to chemotherapy. This can be explained by carcinogenic mechanisms and molecular biological features. Although chemotherapy with cytotoxic anticancer drugs has been evaluated by clinical studies, none have achieved better treatment outcomes than paclitaxel + carboplatin therapy. In recent years, attention has been focused on treatment with molecular target drugs and immune checkpoint inhibitors that target newly identified biomarkers, and many clinical studies on such treatments have been planned.

卵巢透明细胞癌和粘液癌对化疗不太敏感。这可以通过致癌机制和分子生物学特征来解释。尽管已通过临床研究评估了使用细胞毒性抗癌药物进行化疗,但没有一个比紫杉醇+卡铂治疗取得更好的治疗效果。近年来,人们将注意力集中在针对新发现的生物标志物的分子靶向药物和免疫检查点抑制剂的治疗上,并且已经计划了许多关于此类治疗的临床研究。

5L高效摇瓶

5L高效摇瓶

Ovarian cancer has the worst prognosis among gynecological cancers. In particular, clear cell and mucinous carcinomas are less sensitive to chemotherapy. The establishment of new therapies is necessary to improve the treatment outcomes for these carcinomas. In previous clinical studies, chemotherapy with cytotoxic anticancer drugs has failed to demonstrate better treatment outcomes than paclitaxel + carboplatin therapy. In recent years, attention has been focused on treatment with molecular target drugs and immune checkpoint inhibitors that target newly identified biomarkers. The issues that need to be addressed include the most appropriate combination of therapies, identifying patients who may benefit from each therapy, and how results should be incorporated into the standard of care for ovarian clear cell and mucinous carcinomas. In this article, we have reviewed the most promising therapies for ovarian clear cell and mucinous carcinomas, which are regarded as intractable, with an emphasis on therapies currently being investigated in clinical studies.

在妇科癌症中,卵巢癌的预后最差。特别是,透明细胞癌和粘液癌对化疗不太敏感。新疗法的建立对于改善这些癌症的治疗结果是必要的。在之前的临床研究中,细胞毒性抗癌药物化疗未能证明比紫杉醇+卡铂治疗更好的治疗效果。近年来,注意力集中在针对新发现的生物标志物的分子靶向药物和免疫检查点抑制剂的治疗上。需要解决的问题包括最合适的治疗组合,确定可能从每种治疗中受益的患者,以及如何将结果纳入卵巢透明细胞癌和粘液癌的护理标准。

三角细胞摇瓶

三角细胞摇瓶

Ovarian cancer is diverse at the molecular level, and clear cell and mucinous carcinomas exhibit low sensitivity to chemotherapy. Although chemotherapy regimens for ovarian clear cell and mucinous carcinomas have been evaluated by numerous clinical studies, they have failed to exhibit treatment outcomes superior to those of TC therapy. The identification of biomarkers and development of therapeutic drugs specific to each type of ovarian cancer are anticipated. For ovarian clear cell carcinoma, in which the PI3K/AKT/mTOR pathway and the MDM2 gene are prognostic factors, AKT and MDM2 inhibitors may prove to be promising therapeutic drugs in the future. The biomakers for ovarian mucinous carcinoma, including the KRAS and HER2-neu genes, MEK, and PI3K, and molecular target drugs such as trastuzumab, lapatinib, and cetuximab have been gaining attention. We hope that molecular target drugs and immune checkpoint inhibitors targeting these genomic alterations will be developed and clinically applied in the future.

细胞工厂

细胞工厂

卵巢癌在分子水平上是多种多样的,透明细胞癌和粘液癌对化疗的敏感性较低。尽管卵巢透明细胞癌和粘液性癌的化疗方案已通过大量临床研究进行评估,但它们未能表现出优于 TC 治疗的治疗效果。预计针对每种卵巢癌的生物标志物的鉴定和治疗药物的开发。对于卵巢透明细胞癌,其中 PI3K/AKT/mTOR 通路和MDM2基因是预后因素,AKT MDM2抑制剂可能被证明是未来有希望的治疗药物。卵巢粘液癌的生物标志物,包括KRASHER2-neu基因、MEKPI3K,以及曲妥珠单抗、拉帕替尼、西妥昔单抗等分子靶向药物备受关注。我们希望未来能够开发出针对这些基因组改变的分子靶向药物和免疫检查点抑制剂并应用于临床。

关键词: 卵巢癌,透明细胞癌,粘液癌,化疗,临床试验,ovarian cancer,clear cell carcinoma,mucinous carcinoma,chemotherapy, clinical trial

来源:MDPI https://www.mdpi.com/2072-6694/13/23/6120/htm



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