BPA is identified as an endocrine-disrupting chemical that deteriorates the physiological function of the hormones of the male reproductive system. Bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF) are actively explored as substitutes for BPA and are known as BPA analogues in most manufacturing industries. These analogues may demonstrate the same adverse effects as BPA on the male reproductive system; however, toxicological data explaining the male reproductive hormones’ physiological functions are still limited. Hence, this mini-review discusses the effects of BPA and its analogues on the physiological functions of hormones in the male reproductive system, focusing on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, and spermatogenesis outcomes. The BPA analogues mainly show a similar negative effect on the hormones’ physiological functions, proven by alterations in the HPG axis and steroidogenesis via activation of the aromatase activity and reduction of spermatogenesis outcomes when compared to BPA in in vitro and in vivo studies. Human biomonitoring studies also provide significant adverse effects on the physiological functions of hormones in the male reproductive system. In conclusion, BPA and its analogues deteriorate the physiological functions of hormones in the male reproductive system as per in vitro, in vivo, and human biomonitoring studies.

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BPA 被认为是一种内分泌干扰化学物质，会破坏男性生殖系统激素的生理功能。双酚 F (BPF)、双酚 S (BPS) 和双酚 AF (BPAF) 被积极探索作为 BPA 的替代品，在大多数制造业中被称为 BPA 类似物。这些类似物可能表现出与双酚 A 对男性生殖系统相同的不利影响；然而，解释雄性生殖激素生理功能的毒理学数据仍然有限。因此，这篇小型综述讨论了 BPA 及其类似物对男性生殖系统激素生理功能的影响，重点关注下丘脑-垂体-性腺 (HPG) 轴、类固醇生成和精子生成结果。在体外和体内研究中，与 BPA 相比，BPA 类似物主要对激素的生理功能显示出类似的负面影响，这证明了 HPG 轴的改变和类固醇生成通过芳香酶活性的激活和精子发生结果的减少。人体生物监测研究还对男性生殖系统中激素的生理功能产生了显着的不利影响。总之，根据体外、体内和人体生物监测研究，BPA 及其类似物会降低男性生殖系统中激素的生理功能。人体生物监测研究还对男性生殖系统中激素的生理功能产生了显着的不利影响。总之，根据体外、体内和人体生物监测研究，BPA 及其类似物会降低男性生殖系统中激素的生理功能。人体生物监测研究还对男性生殖系统中激素的生理功能产生了显着的不利影响。总之，根据体外、体内和人体生物监测研究，BPA 及其类似物会降低男性生殖系统中激素的生理功能。

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In conclusion, BPA and its analogues may be an additional risk factor to consider because they disrupt the hormonal physiological functions of the male reproductive system. The results of the experimental studies mostly point to BPA and its analogues having the ability to disrupt the endocrine system, resulting in HPG axis disturbances and activation of the steroidogenesis alternative pathway, which is why more experimental and epidemiological research will be required to establish the scale of the effects caused by these chemicals in large populations and its molecular mechanism to a better understanding of the connection between HPG axis, steroidogenesis, and spermatogenesis outcomes. Despite the fact that many nations have adopted policies to limit exposure to BPA and its analogues in their populations, epidemiological research on humans imply that the same abnormalities seen in experimental studies on animals may be detected. Understanding the association between BPA and its analogues and physiological hormonal activities can aid in raising public awareness and implementing public health campaigns to prevent exposure to these compounds, particularly among those attempting to conceive and elderly populations.

总之，双酚 A 及其类似物可能是一个需要考虑的额外风险因素，因为它们会扰乱男性生殖系统的激素生理功能。实验研究的结果大多指向 BPA 及其类似物具有破坏内分泌系统的能力，导致 HPG 轴紊乱和类固醇生成替代途径的激活，这就是为什么需要更多的实验和流行病学研究来建立规模这些化学物质在大量人群中引起的影响及其分子机制，以更好地了解 HPG 轴、类固醇生成和精子生成结果之间的联系。尽管许多国家已采取政策限制其人群接触双酚 A 及其类似物，对人类的流行病学研究表明，可能会检测到动物实验研究中所见的相同异常。了解双酚 A 及其类似物与生理荷尔蒙活动之间的关联，有助于提高公众意识和开展公共卫生运动，以防止接触这些化合物，尤其是那些怀孕的人和老年人。

 
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关键词：Aromatase, bisphenol F,bisphenol AF,bisphenol S,HPG axis,steroidogenesis,芳香化酶,双酚 F,双酚AF,双酚S,HPG 轴,类固醇生成,

来源: MDPI  https://www.mdpi.com/2227-9059/9/11/1744/htm